Novel methothrexate-based topical therapies for effective tr

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Novel methothrexate-based topical therapies for effective tr

Post by sindhu88 on Thu Jul 15, 2010 8:35 pm

To reduce such effects, it would clearly be preferable to administer MTX topically [10]. In spite of several advantages offered by the transdermal route, few molecules can be administered topically/transdermally because of the formidable barrier properties of the stratum corneum (SC). A major problem in this case is the hydrosolubility of the drug and its relatively high molecular weight (454.56). Also the presence of the drug mostly in its dissociated form at physiological pH further limits its capacity for passive diffusion. Hence various techniques have been employed for enhancing the dermal delivery of MTX.

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